Wednesday, July 9, 2008

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Tuesday, July 8, 2008

Nature People

Neuroscientist: my data published without authorization are 'misleading'



On the heels of the open access debate instigated by Declan Butler's recent article in Nature, and after the canonization of St. Logothetis by a number of neurobloggers (this one included), David Poeppel has informed us that the Nature Publishing Group has started an exciting new journal, Nature People. And the first featured science celebrity is none other than Dr. Logothetis himself. Dr. Poeppel offers his opinion on the fledgling publication:
I recommend as reading a piece on the sociology of science and scientific conduct that just came out in Nature. The article tells the embarrassing saga of a dataset acquired by two former Logothetis trainees and published in the journal Human Brain Mapping this past May.

. . . .

The two authors should not have proceeded to the publication stage without involving the PI much more closely, given the origin of the data; the PI should show more perspective and coolitude and chillaxity (both closely related to Stephen Colbert's truthiness) -- and write a calm and carefully argued response, if the stakes are really that high; the journal Human Brain Mapping should have allowed time for a published response, given that that is not uncommon for journals...; Nature should not write about this -- unless this is NPG's new Nature People (nobody wins with this type of hype, I bet).
Here's an excerpt of the actual news story in Nature:

Max Planck researchers charged with misusing data

by Alison Abbott

The director of a top laboratory in Germany has charged that two of his former research students took data from his laboratory without his permission and published scientifically incorrect interpretations of them against his advice.

Neuroscientist Nikos Logothetis (pictured), of the Max Planck Institute for Biological Cybernetics in Tübingen, further claims that the journal involved, Human Brain Mapping, acted incorrectly by publishing the paper after he told them the data were inappropriate. He says the journal has denied him the right to a timely reply.

One of the two editors-in-chief of Human Brain Mapping, Peter Fox of the University of Texas Health Science Center in San Antonio, told Nature that the paper was correctly refereed, but declined to add details.

Logothetis is furious about the publication of data, which he believes will mislead the field, and about the fact that the authors of the paper allege that he tried to stop them publishing the data for personal reasons.

What about the authors?

Shmuel and Leopard [sic] issued a statement to Nature in which they say: “We are confident, and rigorous peer review agreed, that the data we collected are appropriate for studying spontaneous activity and the resting state in the brain. We stand by the conclusions we made in our paper.”

Here's the link to the paper, so you can read it and decide for yourself.

Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest
Human Brain Mapping
Volume 29, Issue 7, Date: July 2008, Pages: 751-761
Amir Shmuel, David A. Leopold
Abstract | References | Full Text: HTML, PDF (1257K)

The incident does raise serious issues of data "ownership" (Logothetis granted the duo permission to use the data, but reneged at a later date), authorship (the first author allegedly "invited Logothetis to join as third author, telling him that the paper had already been accepted for publication and would appear online in a few days"), and "jurisdiction" (What's the proper role of the research institution? Did Logothetis have the right to tell Peter Fox how to run his journal?).

What do you think? How could such a major public imbroglio have been averted?

Take the poll at Talking Brains.
For a given project that a PI starts with one or more students/postdocs, should author order be determined, and other publication issues be settled at the outset of the project?

Nature People... Look for it on a newsstand near you! (or near the lengthy checkout line in the grocery store where there's only one cashier for a disgruntled group of 17 customers).

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Monday, July 7, 2008

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49

Encephalon 49, that is. Challenge yourself neuroscientifically by reading a skeptical view on the use of gene therapy in psychiatry, and then recover by relaxing your genes.



Sunday, July 6, 2008

59

59 is the number of hot dogs consumed in 10 min by the two finalists in the world's most famous competitive eating contest.


128 lb Takeru Kobayashi vs. 210 lb Joey Chestnut at Nathan's Hot Dog Eating Contest held on July 4, 2008.

The contest went into "overtime," which was decided by a 5 hot dog eat-off.
Champ retains NYC hot-dog eating title in overtime

NEW YORK (AP) — Joey Chestnut achieved frankfurter immortality Friday, outdueling his celebrated Japanese rival in an epic hot-dog eating contest that pushed both of the gluttonous gladiators to the brink.

In a seesaw struggle for the ages, Chestnut and Takeru Kobayashi each consumed an eye-popping 59 hot dogs in 10 minutes, forcing an unprecedented showdown that tested the very depths of their distended stomachs.

Under the glare of ESPN and facing a boisterous and sweaty crowd of thousands on Coney Island, Chestnut, the reigning champ, and Kobayashi, the six-time title holder, were forced to gobble down another five hot dogs in overtime.

How do they do it? A Science Daily video from two years ago speculated that Competitive Eaters May Have Ability to Suppress Satiety Hormones:

"These competitive eaters are an interesting group of people who seem to have abilities that many people in the normal population don't have," David Metz, a gastroenterologist at University of Pennsylvania in Philadelphia, tells DBIS.

Many competitive eaters train for an event by chugging gallons of water to help stretch the stomach. Others eat large quantities of low-calorie, high-fiber foods, like cabbage, that stay in the stomach longer before breaking down. Doctors believe expert eaters may have the ability to keep eating after they're full by suppressing the stomach signals to the brain that indicate it's satisfied.

Sounds like a horribly wretched thing to do to your body. But is it dangerous? In an article entitled Competitive Speed Eating: Truth and Consequences, Levine et al. (2007) concluded:
We speculate that professional speed eaters eventually may develop morbid obesity, profound gastroparesis, intractable nausea and vomiting, and even the need for a gastrectomy. Despite its growing popularity, competitive speed eating is a potentially self-destructive form of behavior.


Wiry 128 lb. Takeru Kobayashi.

Of course, there do appear to be notable exceptions...

For great coverage of the Levine et al. article in the American Journal of Roentgenology, read Radiology of Competitive Speed Eating at Not Totally Rad. From the abstract:
The purpose of our investigation was to assess the stomachs of a world-class speed-eating champion and of a control subject during a speed-eating test in our gastrointestinal fluoroscopy suite to determine how competitive speed eaters are able to eat so much so fast.
The Wall Street Journal Health Blog also describes the paper (complete with gastrointestinal fluoroscopic images) and interviews radiologist Marc Levine. The study compared "an unnamed champion eater, ranked in the top 10 in the world, who was 29 years old, 5′10″ tall and weighed 165 pounds" to "just some guy who 'had a hearty appetite' (35 years old, 6′2″, 201 pounds)."

The regular guy went first, and stopped after seven dogs... Using fluoroscopy, an x-ray that gives a real-time view of what’s going on inside the body, the doctors saw what you’d expect: His stomach was indeed full of hot dogs and hadn’t stretched much from its original size.

Then they looked at the competitive eater. First, they noticed that his empty stomach showed virtually no peristalsis, the normal squeezing motion that helps the stomach break down food. He started eating hot dogs and his stomach got bigger and bigger. Ten minutes in, he’d eaten 36 dogs. He said he didn’t feel full, but the researchers told him they’d seen enough.

“His stomach now appeared as a massively distended, foodfilled sac occupying most of the upper abdomen, with little or no gastric peristalsis,” they wrote in their paper. Levine said the stomach was like no healthy stomach he’d seen in his 30-year career. He compared it to a “giant balloon that looks like it has no limit.” The eater’s previously flat belly swelled out as if he were pregnant.

Just how much fat, cholesterol, sodium nitrite, MSG, etc. is in 4-5 pounds of hot dogs, you ask? A serving of 36 Nathan's Famous Beef Franks has 6120 calories, 540 g fat, 1260 mg cholesterol, and 16,920 mg sodium. Organic fat-free veggie dogs, anyone?

Saturday, July 5, 2008

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